George (Richard Gere), is an increasingly desperate man. Life seems to have passed him by. With nowhere to turn, he finds himself adrift on the unforgiving streets of New York City. After exhausting all possible housing options, he seeks refuge at Bellevue Hospital, Manhattan's largest intake center for homeless men. It proves a harsh and bewildering environment, teeming with marginalized souls. But when George befriends a seasoned shelter-dweller, he begins to find hope of repairing his relationship with his estranged daughter (Jena Malone). Featuring a tour de force performance by Gere, TIME OUT OF MIND tells the story of those that have become invisible to the modern world.